报告时间：2024年5月30日10：00-11：00
报告地点：博远楼 206
报告人：Albert Goldbeter，布鲁塞尔自由大学
报告摘要：Abstract
To assess the toxicity of various circadian patterns of anticancer drug delivery so as to enhance the efficiency of cancer chronotherapy, we need a model for the mammalian cell cycle. We developed two complementary approaches to cell cycle modeling. One is a detailed model for the cyclin/Cdk network driving the mammalian cell cycle. The second approach represents a stochastic automaton model for the cell cycle. Based on the sequential transitions between the successive phases G1, S (DNA replication), G2, and M (mitosis) of the cell cycle, the model allows us to simulate the distribution of cell cycle phases as well as entrainment by the circadian clock. We used the model to evaluate circadian patterns of administration of two anticancer drugs, 5-fluorouracil (5-FU) and oxaliplatin (l-OHP). The results indicate that the same temporal pattern of drug administration can have minimum cytotoxicity toward one cell population, e.g. of normal cells, and at the same time can display high cytotoxicity toward a second cell population, e.g. of tumor cells. Thus the model allows us to uncover factors that may contribute to improve simultaneously the chronotolerance and chronoefficacy of anticancer drugs.
报告人简介： Albert Goldbeter教授是比利时布鲁塞尔自由大学（Université libre de Bruxelles，简称ULB）的杰出教授，比利时皇家科学院院士。Goldbeter教授以在数学生物学和系统生物学领域的贡献而闻名，专注于生物节律和振荡的研究，在昼夜节律、细胞周期调控和生化信号网络的机制方面做出了重要贡献。Goldbeter教授发表了许多有影响力的论文，并在系统生物学领域撰写了多本书籍。他的研究获得了国际认可，并对生物过程的理解产生了深远影响。
邀请人： 颜洁